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<i>In vitro</i> and <i>in vivo</i> anti-cancer effects of 2-ethyl-3-<i>O</i>-sulphamoyl-estra-1,3,5(10)15-tetraene-3-ol-17-one and 2-ethyl-3-<i>O</i>-sulphamoyl-estra-1,3,5(10)16-tetraene